Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Rare2MethodGenes-q0-01 Exclusive	Familial	4.11e-09	6.59e-11	2.33e-12	5.51e-16
Familial Exclusive	Rare2MethodGenes-q0-01	1.17e-02	3.03e-02	7.90e-06	2.97e-03
Rare2MethodGenes-q0-01 Exclusive	Familial Exclusive	6.56e-06	6.58e-08	4.55e-08	7.49e-12
Familial Exclusive	Rare2MethodGenes-q0-01 Exclusive	2.51e-01	6.70e-01	3.23e-06	5.21e-03
Rare2MethodGenes-q0-01 Exclusive	Overlap	1.39e-06	2.61e-05	5.61e-07	4.71e-07
Familial Exclusive	Overlap	3.30e-07	4.71e-07	3.30e-07	3.45e-07
Overlap	Exclusives	9.66e-07	5.55e-05	7.86e-19	1.37e-08



Evaluating how well Rare2MethodGenes-q0-01 genes are linked to Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes-q0-01 Exclusive	Familial	0.93	1.84	7.01	2.19	9.75
Familial Exclusive	Rare2MethodGenes-q0-01	0.63	2.50	1.29	1.47	4.13
Rare2MethodGenes-q0-01 Exclusive	Familial Exclusive	0.92	1.71	5.66	2.13	6.90
Familial Exclusive	Rare2MethodGenes-q0-01 Exclusive	0.60	2.51	0.65	0.99	3.35
Rare2MethodGenes-q0-01 Exclusive	Overlap	0.99	2.17	4.01	2.22	4.35
Familial Exclusive	Overlap	1.00	2.16	3.64	2.87	5.00
Overlap	Exclusives	0.71	2.08	4.01	2.68	7.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes-q0-01 Exclusive	Familial	0.03	2.29	33.30	8.65	46.12
Familial Exclusive	Rare2MethodGenes-q0-01	0.06	22.03	60.71	55.77	77.63
Rare2MethodGenes-q0-01 Exclusive	Familial Exclusive	0.02	1.90	23.64	6.22	42.81
Familial Exclusive	Rare2MethodGenes-q0-01 Exclusive	0.02	46.12	24.21	30.79	36.88
Rare2MethodGenes-q0-01 Exclusive	Overlap	0.02	4.18	31.41	11.12	38.14
Familial Exclusive	Overlap	0.16	7.84	229.79	144.83	523.64
Overlap	Exclusives	0.04	15.76	42.22	29.96	56.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Rare2MethodGenes-q0-01 Exclusive	85	82	;SSPO;C4B_2
Familial Exclusive	24	24	
Overlap	7	7