Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Rare2MethodGenes-q0-01 Exclusive	GWAS	7.89e-01	4.41e-01	1.96e-02	1.88e-05
GWAS Exclusive	Rare2MethodGenes-q0-01	7.82e-01	1.73e-01	1.41e-05	4.39e-04
Rare2MethodGenes-q0-01 Exclusive	GWAS Exclusive	8.42e-01	4.15e-01	1.30e-02	1.90e-05
GWAS Exclusive	Rare2MethodGenes-q0-01 Exclusive	7.95e-01	2.50e-01	1.01e-04	6.92e-03
Rare2MethodGenes-q0-01 Exclusive	Overlap	6.77e-02	6.77e-02	6.77e-02	7.24e-02
GWAS Exclusive	Overlap	1.48e-02	1.29e-02	3.16e-03	5.27e-04
Overlap	Exclusives	9.50e-04	1.11e-02	3.48e-32	5.42e-13



Evaluating how well Rare2MethodGenes-q0-01 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes-q0-01 Exclusive	GWAS	0.63	0.96	1.31	1.44	5.43
GWAS Exclusive	Rare2MethodGenes-q0-01	0.62	0.78	1.02	1.30	3.65
Rare2MethodGenes-q0-01 Exclusive	GWAS Exclusive	0.62	0.98	1.45	1.51	5.02
GWAS Exclusive	Rare2MethodGenes-q0-01 Exclusive	0.59	0.61	0.63	0.80	3.16
Rare2MethodGenes-q0-01 Exclusive	Overlap	0.75	-0.87	-0.26	-0.00	2.21
GWAS Exclusive	Overlap	0.93	1.06	1.68	2.39	3.82
Overlap	Exclusives	0.65	2.79	3.97	2.21	9.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes-q0-01 Exclusive	GWAS	0.01	0.14	1.57	2.08	6.78
GWAS Exclusive	Rare2MethodGenes-q0-01	0.02	2.77	22.05	20.91	30.97
Rare2MethodGenes-q0-01 Exclusive	GWAS Exclusive	0.01	-0.70	0.55	0.89	3.45
GWAS Exclusive	Rare2MethodGenes-q0-01 Exclusive	0.02	2.79	26.02	17.93	23.81
Rare2MethodGenes-q0-01 Exclusive	Overlap	0.01	5.83	33.47	8.59	38.09
GWAS Exclusive	Overlap	0.01	2.33	2.73	18.56	2.53
Overlap	Exclusives	0.03	4.99	9.66	7.52	13.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Rare2MethodGenes-q0-01 Exclusive	85	83	C4B_2;SSPO
GWAS Exclusive	162	162	
Overlap	7	6