Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AllVar2MethodGenes Exclusive	Somatic	5.30e-01	2.55e-01	1.27e-02	6.08e-10
Somatic Exclusive	AllVar2MethodGenes	2.88e-02	9.54e-01	2.69e-06	3.27e-01
AllVar2MethodGenes Exclusive	Somatic Exclusive	5.06e-01	3.59e-01	3.94e-02	1.89e-09
Somatic Exclusive	AllVar2MethodGenes Exclusive	3.34e-02	9.73e-01	6.96e-06	3.71e-01
AllVar2MethodGenes Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Somatic Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Overlap	Exclusives	5.76e-11	5.52e-10	7.88e-22	4.15e-13



Evaluating how well AllVar2MethodGenes genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AllVar2MethodGenes Exclusive	Somatic	0.82	-0.99	1.10	0.36	7.11
Somatic Exclusive	AllVar2MethodGenes	0.55	-0.68	-0.39	0.03	2.04
AllVar2MethodGenes Exclusive	Somatic Exclusive	0.81	-1.10	0.85	0.31	6.51
Somatic Exclusive	AllVar2MethodGenes Exclusive	0.54	-0.42	-0.67	-0.08	1.59
AllVar2MethodGenes Exclusive	Overlap	1.00	1.70	2.71	1.46	2.60
Somatic Exclusive	Overlap	0.99	1.10	2.37	1.82	2.68
Overlap	Exclusives	0.66	0.82	3.09	1.86	7.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AllVar2MethodGenes Exclusive	Somatic	0.01	-1.06	2.70	0.21	11.47
Somatic Exclusive	AllVar2MethodGenes	0.01	-0.45	0.68	0.87	1.84
AllVar2MethodGenes Exclusive	Somatic Exclusive	0.01	-1.36	0.94	-0.41	7.30
Somatic Exclusive	AllVar2MethodGenes Exclusive	0.01	-0.45	-0.28	0.40	1.06
AllVar2MethodGenes Exclusive	Overlap	0.03	54.94	135.91	28.26	36.60
Somatic Exclusive	Overlap	0.01	0.47	38.56	27.62	14.77
Overlap	Exclusives	0.03	18.68	21.59	9.73	22.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AllVar2MethodGenes Exclusive	135	132	;DKK 3.00;GPR75-ASB3
Somatic Exclusive	38	38	
Overlap	2	2