Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AllVar2MethodGenes-q0-01 Exclusive	Somatic	1.21e-01	8.93e-01	1.84e-01	1.41e-09
Somatic Exclusive	AllVar2MethodGenes-q0-01	7.34e-03	5.73e-01	1.45e-03	4.35e-02
AllVar2MethodGenes-q0-01 Exclusive	Somatic Exclusive	8.25e-02	8.90e-01	1.81e-01	1.11e-08
Somatic Exclusive	AllVar2MethodGenes-q0-01 Exclusive	5.49e-03	5.44e-01	9.69e-04	4.97e-02
AllVar2MethodGenes-q0-01 Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.28e-02
Somatic Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	6.99e-15	1.12e-12	2.43e-22	1.22e-17



Evaluating how well AllVar2MethodGenes-q0-01 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AllVar2MethodGenes-q0-01 Exclusive	Somatic	0.79	-1.14	0.48	0.29	6.86
Somatic Exclusive	AllVar2MethodGenes-q0-01	0.58	-1.02	-1.03	-0.54	2.62
AllVar2MethodGenes-q0-01 Exclusive	Somatic Exclusive	0.78	-1.52	0.23	0.33	5.67
Somatic Exclusive	AllVar2MethodGenes-q0-01 Exclusive	0.57	-0.89	-1.23	-0.44	2.21
AllVar2MethodGenes-q0-01 Exclusive	Overlap	1.00	1.54	2.37	1.57	2.29
Somatic Exclusive	Overlap	0.99	1.02	2.48	1.84	2.39
Overlap	Exclusives	0.73	1.32	3.69	2.17	9.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AllVar2MethodGenes-q0-01 Exclusive	Somatic	0.01	-1.03	2.00	0.63	2.06
Somatic Exclusive	AllVar2MethodGenes-q0-01	0.01	-0.47	0.33	0.74	4.80
AllVar2MethodGenes-q0-01 Exclusive	Somatic Exclusive	0.01	-1.40	0.10	-0.10	0.73
Somatic Exclusive	AllVar2MethodGenes-q0-01 Exclusive	0.00	-0.50	-0.62	0.42	1.96
AllVar2MethodGenes-q0-01 Exclusive	Overlap	0.02	20.40	93.24	32.08	5.27
Somatic Exclusive	Overlap	0.01	-0.01	39.05	12.51	39.39
Overlap	Exclusives	0.03	28.58	33.14	11.52	25.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AllVar2MethodGenes-q0-01 Exclusive	75	74	
Somatic Exclusive	38	38	
Overlap	2	2