Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
intersect_29	GS	1.39e-02	6.73e-03	7.42e-02	2.58e-04
GS	intersect_29	4.63e-01	5.16e-01	7.48e-02	4.05e-01



Evaluating how well intersect_29 genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
intersect_29	GS	0.81	2.18	3.84	1.58	3.73
GS	intersect_29	0.52	1.01	0.66	1.00	0.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
intersect_29	GS	0.00	2.80	4.30	2.46	2.96
GS	intersect_29	0.00	2.56	2.27	2.47	1.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
intersect_29	29	29	
GS	14	14