Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
intersect_29 Exclusive	GWAS	1.61e-06	1.30e-07	2.07e-05	1.50e-08
GWAS Exclusive	intersect_29	3.25e-01	1.76e-01	8.08e-02	9.06e-02
intersect_29 Exclusive	GWAS Exclusive	1.86e-06	1.40e-07	1.04e-05	7.00e-08
GWAS Exclusive	intersect_29 Exclusive	2.66e-01	1.98e-01	1.20e-01	2.36e-01
intersect_29 Exclusive	Overlap	1.49e-01	9.92e-02	1.85e-01	1.85e-01
GWAS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
Overlap	Exclusives	1.52e-02	1.23e-05	5.39e-17	3.26e-06



Evaluating how well intersect_29 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
intersect_29 Exclusive	GWAS	0.82	3.57	6.05	2.85	5.44
GWAS Exclusive	intersect_29	0.54	1.65	1.15	0.94	0.93
intersect_29 Exclusive	GWAS Exclusive	0.82	3.33	5.44	3.15	5.72
GWAS Exclusive	intersect_29 Exclusive	0.52	1.54	0.86	0.83	0.46
intersect_29 Exclusive	Overlap	0.94	1.12	-75079424282334.00	1.20	1.24
GWAS Exclusive	Overlap	1.00	1.33	111424462830387.00	1.76	1.63
Overlap	Exclusives	0.69	662184206897890.00	4.98	2.54	4.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
intersect_29 Exclusive	GWAS	0.00	2.24	6.49	1.44	6.51
GWAS Exclusive	intersect_29	0.01	3.43	0.90	0.94	0.59
intersect_29 Exclusive	GWAS Exclusive	0.00	3.74	6.26	3.80	1.61
GWAS Exclusive	intersect_29 Exclusive	0.00	3.94	0.37	4.40	4.20
intersect_29 Exclusive	Overlap	0.00	0.79	-368040793801695.00	0.54	-0.05
GWAS Exclusive	Overlap	0.02	45.19	32920936630948200.00	60.45	4.41
Overlap	Exclusives	0.02	12529040294954694.00	16.95	13.34	19.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
intersect_29 Exclusive	28	28	
GWAS Exclusive	24	23	HLA -DRB1
Overlap	1	1