Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Private_to_Combined	GS	5.55e-02	1.97e-01	1.34e-01	1.91e-03
GS	Private_to_Combined	3.74e-01	3.74e-01	2.56e-03	4.64e-01



Evaluating how well Private_to_Combined genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Private_to_Combined	GS	0.76	1.46	2.13	1.24	3.19
GS	Private_to_Combined	0.57	2.26	1.65	1.50	0.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Private_to_Combined	GS	0.00	3.99	5.55	1.37	2.87
GS	Private_to_Combined	0.00	2.40	3.34	1.46	1.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Private_to_Combined	24	24	
GS	14	14