Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Private_to_Combined	GWAS25	8.29e-01	5.88e-01	4.36e-01	1.05e-01
GWAS25	Private_to_Combined	3.58e-01	6.83e-01	3.21e-01	5.50e-01



Evaluating how well Private_to_Combined genes are linked to GWAS25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Private_to_Combined	GWAS25	0.56	-0.69	-1.55	-0.86	1.09
GWAS25	Private_to_Combined	0.51	0.63	0.35	0.27	0.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Private_to_Combined	GWAS25	0.00	-0.77	-1.22	-0.32	-0.21
GWAS25	Private_to_Combined	0.00	-0.29	-0.40	-0.16	-0.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Private_to_Combined	24	24	
GWAS25	25	24	HLA -DRB1