Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Private_to_Male	GS	4.79e-01	2.75e-01	9.64e-01	1.73e-01
GS	Private_to_Male	5.28e-01	7.71e-01	1.36e-02	4.20e-01



Evaluating how well Private_to_Male genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Private_to_Male	GS	0.64	0.50	1.12	0.04	1.91
GS	Private_to_Male	0.45	0.51	-0.61	-0.16	-1.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Private_to_Male	GS	0.00	0.43	0.02	0.04	1.75
GS	Private_to_Male	0.00	0.47	-0.12	-0.08	-0.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Private_to_Male	72	71	LOC728392
GS	14	14