Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Private_to_Male	GWAS	7.26e-08	8.30e-09	2.10e-06	3.94e-10
GWAS	Private_to_Male	3.72e-01	5.24e-01	3.85e-01	5.28e-01



Evaluating how well Private_to_Male genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Private_to_Male	GWAS	0.84	3.33	4.99	3.39	5.65
GWAS	Private_to_Male	0.49	1.11	0.73	0.64	-0.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Private_to_Male	GWAS	0.01	5.79	9.85	5.34	8.28
GWAS	Private_to_Male	0.01	9.57	7.79	6.88	2.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Private_to_Male	72	71	LOC728392
GWAS	25	24	HLA -DRB1