Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Private_to_Female	GS	2.17e-01	2.07e-01	9.27e-02	5.71e-02
GS	Private_to_Female	1.11e-03	3.34e-01	2.15e-03	4.73e-02



Evaluating how well Private_to_Female genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Private_to_Female	GS	0.59	-0.44	-1.29	-0.70	1.17
GS	Private_to_Female	0.45	-0.71	-0.54	-0.26	-1.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Private_to_Female	GS	0.00	-0.43	-0.92	-0.68	-0.04
GS	Private_to_Female	0.00	-0.31	-0.51	-0.48	-1.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Private_to_Female	67	66	FIGNL2
GS	14	14