Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Private_to_Female	GWAS	1.09e-03	1.31e-03	2.35e-02	1.38e-06
GWAS	Private_to_Female	4.95e-01	5.63e-02	1.05e-02	5.53e-01



Evaluating how well Private_to_Female genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Private_to_Female	GWAS	0.80	2.77	4.48	2.73	4.86
GWAS	Private_to_Female	0.53	2.17	1.92	1.97	0.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Private_to_Female	GWAS	0.00	1.65	6.35	1.40	5.57
GWAS	Private_to_Female	0.00	2.37	0.22	2.94	2.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Private_to_Female	67	66	FIGNL2
GWAS	25	24	HLA -DRB1