Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
01_5 Exclusive	Ref	4.67e-04	1.13e-01	4.11e-01	1.37e-08
Ref Exclusive	01_5	9.81e-02	8.62e-01	9.32e-05	6.60e-03
01_5 Exclusive	Ref Exclusive	3.88e-04	1.14e-01	4.16e-01	1.45e-07
Ref Exclusive	01_5 Exclusive	7.38e-02	5.86e-01	7.84e-04	3.70e-02
01_5 Exclusive	Overlap	9.98e-01	8.14e-01	5.74e-01	7.15e-02
Ref Exclusive	Overlap	1.38e-03	1.85e-03	1.38e-03	1.85e-03
Overlap	Exclusives	9.57e-14	2.25e-15	1.12e-60	4.52e-30



Evaluating how well 01_5 genes are linked to Ref genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
01_5 Exclusive	Ref	0.67	-1.66	-2.01	-0.48	5.89
Ref Exclusive	01_5	0.60	-0.86	-0.21	0.32	3.41
01_5 Exclusive	Ref Exclusive	0.66	-1.80	-2.28	-0.49	5.96
Ref Exclusive	01_5 Exclusive	0.58	-1.23	-0.46	-0.24	2.49
01_5 Exclusive	Overlap	0.83	0.28	0.64	0.78	2.16
Ref Exclusive	Overlap	1.00	3.30	2.50	2.21	3.01
Overlap	Exclusives	0.78	4.27	8.73	2.36	13.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
01_5 Exclusive	Ref	0.01	-1.62	-1.61	-0.54	3.02
Ref Exclusive	01_5	0.01	-0.83	1.37	2.23	4.85
01_5 Exclusive	Ref Exclusive	0.01	-1.75	-1.77	-0.63	2.42
Ref Exclusive	01_5 Exclusive	0.00	-1.03	-1.31	-0.63	0.11
01_5 Exclusive	Overlap	0.00	-1.05	-0.63	-0.05	0.11
Ref Exclusive	Overlap	0.05	0.15	103.13	53.69	5.37
Overlap	Exclusives	0.06	17.73	50.60	12.63	72.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
01_5 Exclusive	70	70	
Ref Exclusive	108	105	PRODH;SHANK3;MIR137
Overlap	3	3