Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1_4 Exclusive	Ref	2.96e-01	3.03e-01	3.50e-04	4.30e-17
Ref Exclusive	1_4	4.87e-04	7.19e-01	1.71e-05	6.53e-04
1_4 Exclusive	Ref Exclusive	5.58e-01	2.69e-01	1.81e-04	1.32e-15
Ref Exclusive	1_4 Exclusive	1.76e-04	7.35e-01	8.27e-05	1.21e-03
1_4 Exclusive	Overlap	7.93e-01	5.87e-01	3.51e-01	2.38e-02
Ref Exclusive	Overlap	1.69e-04	1.65e-03	1.69e-04	1.95e-04
Overlap	Exclusives	7.15e-14	1.27e-15	1.26e-54	5.08e-25



Evaluating how well 1_4 genes are linked to Ref genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1_4 Exclusive	Ref	0.74	0.03	1.23	0.96	7.96
Ref Exclusive	1_4	0.60	-1.95	-0.17	0.06	4.14
1_4 Exclusive	Ref Exclusive	0.74	0.23	1.07	0.89	9.67
Ref Exclusive	1_4 Exclusive	0.59	-1.98	-0.60	-0.20	3.38
1_4 Exclusive	Overlap	0.81	-0.29	-0.06	0.50	2.10
Ref Exclusive	Overlap	1.00	3.25	2.49	2.70	3.54
Overlap	Exclusives	0.75	3.65	8.90	2.54	12.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1_4 Exclusive	Ref	0.01	-1.50	-0.14	-0.13	8.43
Ref Exclusive	1_4	0.01	0.77	6.10	4.19	14.05
1_4 Exclusive	Ref Exclusive	0.01	-1.36	-0.19	-0.18	6.47
Ref Exclusive	1_4 Exclusive	0.01	-1.21	-0.07	0.04	2.82
1_4 Exclusive	Overlap	0.00	-0.93	-0.82	-0.63	2.12
Ref Exclusive	Overlap	0.13	3.24	204.35	212.93	248.31
Overlap	Exclusives	0.08	21.86	65.52	18.64	80.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1_4 Exclusive	120	120	
Ref Exclusive	107	104	SHANK3;PRODH;MIR137
Overlap	4	4