Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1_5 Exclusive	ref	2.60e-03	1.22e-01	1.31e-02	1.96e-12
ref Exclusive	1_5	4.39e-03	8.35e-01	1.87e-06	1.66e-03
1_5 Exclusive	ref Exclusive	9.31e-03	2.02e-01	3.35e-02	3.49e-12
ref Exclusive	1_5 Exclusive	4.40e-03	6.05e-01	4.72e-06	2.29e-03
1_5 Exclusive	Overlap	7.33e-01	7.74e-01	8.14e-01	2.21e-01
ref Exclusive	Overlap	1.38e-03	1.60e-03	1.38e-03	1.53e-03
Overlap	Exclusives	1.41e-10	2.09e-11	1.02e-60	1.25e-26



Evaluating how well 1_5 genes are linked to ref genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1_5 Exclusive	ref	0.70	-1.61	-1.96	-0.11	7.48
ref Exclusive	1_5	0.60	-1.96	-0.42	0.20	4.08
1_5 Exclusive	ref Exclusive	0.70	-1.79	-1.84	-0.17	6.70
ref Exclusive	1_5 Exclusive	0.59	-1.91	-0.45	0.04	3.60
1_5 Exclusive	Overlap	0.76	-0.60	-0.66	-0.06	1.54
ref Exclusive	Overlap	1.00	2.77	2.75	2.27	3.36
Overlap	Exclusives	0.73	4.10	7.93	2.32	11.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1_5 Exclusive	ref	0.01	-1.68	-1.94	-0.56	8.10
ref Exclusive	1_5	0.01	-1.35	0.37	0.98	5.73
1_5 Exclusive	ref Exclusive	0.01	-1.93	-1.81	-0.64	7.49
ref Exclusive	1_5 Exclusive	0.01	-1.76	-1.10	-0.42	1.01
1_5 Exclusive	Overlap	0.00	-0.27	-0.93	-0.21	0.28
ref Exclusive	Overlap	0.05	0.49	127.48	56.72	166.08
Overlap	Exclusives	0.05	15.68	39.54	10.52	42.86

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1_5 Exclusive	123	123	
ref Exclusive	108	105	PRODH;MIR137;SHANK3
Overlap	3	3