Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
01_5 Exclusive	GWAS	5.53e-01	7.56e-01	1.98e-03	2.22e-03
GWAS Exclusive	01_5	8.13e-01	8.13e-01	3.96e-01	2.98e-03
01_5 Exclusive	GWAS Exclusive	5.85e-01	8.11e-01	2.95e-03	5.34e-03
GWAS Exclusive	01_5 Exclusive	9.28e-01	7.99e-01	4.79e-01	1.35e-03
01_5 Exclusive	Overlap	6.52e-02	5.40e-01	1.15e-02	1.35e-02
GWAS Exclusive	Overlap	8.16e-01	5.40e-01	5.66e-01	5.53e-01
Overlap	Exclusives	5.97e-03	6.68e-02	1.59e-77	6.36e-07



Evaluating how well 01_5 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
01_5 Exclusive	GWAS	0.55	0.53	0.46	0.80	3.38
GWAS Exclusive	01_5	0.64	1.03	1.36	0.76	4.17
01_5 Exclusive	GWAS Exclusive	0.55	0.47	0.40	0.58	2.84
GWAS Exclusive	01_5 Exclusive	0.64	0.63	1.34	0.57	4.22
01_5 Exclusive	Overlap	0.99	3.15	2.20	2.50	2.38
GWAS Exclusive	Overlap	0.72	0.77	0.38	0.39	1.24
Overlap	Exclusives	0.59	6.62	2.04	1.06	6.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
01_5 Exclusive	GWAS	0.02	0.34	0.50	0.68	2.04
GWAS Exclusive	01_5	0.01	-1.30	0.81	-0.25	3.15
01_5 Exclusive	GWAS Exclusive	0.02	0.18	0.14	0.19	1.34
GWAS Exclusive	01_5 Exclusive	0.01	-0.88	0.74	-0.23	3.06
01_5 Exclusive	Overlap	0.01	2.22	66.02	21.74	3.03
GWAS Exclusive	Overlap	0.01	-0.85	68.40	0.35	1.67
Overlap	Exclusives	0.03	8.88	4.77	3.03	7.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
01_5 Exclusive	71	71	
GWAS Exclusive	302	290	C1orf132;MIR137;AL049840.1;C16orf86;AC027228.1;TMEM110-MUSTN1;C3orf49;MIR548AJ2;PCGEM1;AC005477.1;PAK6;VPS14C
Overlap	2	2