Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
01_04 Exclusive	GWAS	3.23e-02	7.87e-02	4.08e-03	1.48e-04
GWAS Exclusive	01_04	9.67e-02	4.33e-01	7.15e-01	8.07e-04
01_04 Exclusive	GWAS Exclusive	1.04e-02	2.02e-01	5.23e-03	1.86e-04
GWAS Exclusive	01_04 Exclusive	6.64e-02	2.21e-01	7.20e-01	1.89e-03
01_04 Exclusive	Overlap	7.88e-02	7.88e-02	4.43e-03	4.43e-03
GWAS Exclusive	Overlap	4.92e-01	6.16e-01	6.80e-01	4.60e-02
Overlap	Exclusives	1.28e-03	6.82e-02	9.74e-71	1.20e-07



Evaluating how well 01_04 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
01_04 Exclusive	GWAS	0.55	0.69	0.45	0.64	2.99
GWAS Exclusive	01_04	0.61	-0.93	-0.50	-0.59	3.53
01_04 Exclusive	GWAS Exclusive	0.54	0.37	-0.21	0.27	2.87
GWAS Exclusive	01_04 Exclusive	0.60	-0.91	-0.73	-0.53	2.56
01_04 Exclusive	Overlap	0.98	2.29	2.65	2.39	3.09
GWAS Exclusive	Overlap	0.77	-0.26	0.05	0.35	1.71
Overlap	Exclusives	0.59	5.63	2.65	1.65	6.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
01_04 Exclusive	GWAS	0.02	0.69	0.38	0.86	2.05
GWAS Exclusive	01_04	0.01	-0.81	0.41	-0.40	3.45
01_04 Exclusive	GWAS Exclusive	0.02	-0.41	-0.63	-0.24	1.08
GWAS Exclusive	01_04 Exclusive	0.00	-0.79	-0.39	-0.41	0.60
01_04 Exclusive	Overlap	0.03	14.97	59.43	37.31	103.03
GWAS Exclusive	Overlap	0.00	-0.81	2.64	0.16	6.23
Overlap	Exclusives	0.03	6.98	10.89	6.97	14.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
01_04 Exclusive	66	66	
GWAS Exclusive	301	289	VPS14C;AL049840.1;PCGEM1;C16orf86;C3orf49;PAK6;TMEM110-MUSTN1;AC005477.1;MIR137;MIR548AJ2;AC027228.1;C1orf132
Overlap	3	3