Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1_5 Exclusive	GWAS	5.28e-02	3.44e-02	4.78e-04	7.21e-02
GWAS Exclusive	1_5	4.89e-01	6.93e-01	5.46e-01	1.03e-03
1_5 Exclusive	GWAS Exclusive	2.38e-02	3.38e-02	1.21e-03	4.95e-02
GWAS Exclusive	1_5 Exclusive	3.53e-01	4.47e-01	6.40e-01	2.07e-03
1_5 Exclusive	Overlap	2.39e-01	8.14e-01	8.14e-02	8.41e-02
GWAS Exclusive	Overlap	2.21e-01	3.00e-01	3.15e-01	3.15e-01
Overlap	Exclusives	2.14e-03	4.85e-02	4.64e-49	9.66e-09



Evaluating how well 1_5 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1_5 Exclusive	GWAS	0.53	-0.94	-1.77	-0.49	1.68
GWAS Exclusive	1_5	0.61	-0.35	-0.15	-0.07	3.96
1_5 Exclusive	GWAS Exclusive	0.53	-1.04	-1.81	-0.57	1.87
GWAS Exclusive	1_5 Exclusive	0.60	-0.72	-0.52	-0.34	3.48
1_5 Exclusive	Overlap	0.68	1.99	1.20	0.92	1.30
GWAS Exclusive	Overlap	0.77	3.18	2.10	1.84	1.51
Overlap	Exclusives	0.60	5.31	1.86	1.33	6.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1_5 Exclusive	GWAS	0.02	-0.49	-0.49	0.06	1.32
GWAS Exclusive	1_5	0.01	-1.39	-0.02	-0.94	3.50
1_5 Exclusive	GWAS Exclusive	0.02	-0.83	-1.12	-0.39	0.76
GWAS Exclusive	1_5 Exclusive	0.01	-1.51	-0.50	-1.06	2.83
1_5 Exclusive	Overlap	0.01	0.03	32.19	4.34	31.49
GWAS Exclusive	Overlap	0.01	-0.68	9.88	0.20	17.17
Overlap	Exclusives	0.03	8.64	4.30	3.19	9.86

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1_5 Exclusive	123	123	
GWAS Exclusive	301	289	MIR548AJ2;TMEM110-MUSTN1;AC005477.1;VPS14C;C1orf132;C3orf49;MIR137;AC027228.1;PCGEM1;AL049840.1;C16orf86;PAK6
Overlap	3	3