Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA Exclusive	Ref	3.89e-03	1.82e-02	6.35e-06	4.25e-15
Ref Exclusive	EA	3.23e-01	7.65e-01	9.09e-01	3.93e-01
EA Exclusive	Ref Exclusive	3.24e-03	3.01e-02	3.71e-05	9.14e-15
Ref Exclusive	EA Exclusive	2.83e-01	7.91e-01	9.05e-01	3.44e-01
EA Exclusive	Overlap	6.11e-01	3.20e-01	2.28e-01	7.14e-01
Ref Exclusive	Overlap	4.00e-01	3.06e-01	1.75e-01	4.00e-01
Overlap	Exclusives	2.09e-01	2.10e-02	1.18e-06	1.13e-04



Evaluating how well EA genes are linked to Ref genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA Exclusive	Ref	0.64	-1.03	-2.43	-1.07	5.63
Ref Exclusive	EA	0.42	-1.02	-0.97	-1.00	-1.46
EA Exclusive	Ref Exclusive	0.65	-1.14	-2.07	-1.04	5.60
Ref Exclusive	EA Exclusive	0.41	-1.07	-1.67	-1.41	-1.64
EA Exclusive	Overlap	0.56	-0.52	-0.83	-0.87	0.40
Ref Exclusive	Overlap	0.74	-0.32	0.60	0.43	0.83
Overlap	Exclusives	0.61	-0.41	-2.62	-0.71	4.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA Exclusive	Ref	0.01	-1.08	-2.19	-1.08	2.14
Ref Exclusive	EA	0.00	-1.28	-0.99	-1.05	-0.58
EA Exclusive	Ref Exclusive	0.01	-1.13	-1.84	-1.05	0.81
Ref Exclusive	EA Exclusive	0.00	-1.35	-1.19	-1.19	-0.58
EA Exclusive	Overlap	0.00	-0.43	-0.52	-0.45	-0.11
Ref Exclusive	Overlap	0.00	-0.41	-0.29	-0.19	-0.14
Overlap	Exclusives	0.01	-0.44	-1.76	-0.58	2.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA Exclusive	30	29	LOC554223
Ref Exclusive	110	107	PRODH;MIR137;SHANK3
Overlap	1	1