Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA Exclusive	Ref	6.94e-02	7.46e-01	2.03e-01	9.62e-12
Ref Exclusive	EA	4.75e-03	3.50e-01	7.09e-02	3.47e-01
EA Exclusive	Ref Exclusive	1.14e-01	6.01e-01	2.23e-01	4.57e-11
Ref Exclusive	EA Exclusive	6.18e-03	4.05e-01	6.88e-02	5.91e-01
EA Exclusive	Overlap	5.01e-01	4.17e-01	9.90e-01	3.62e-01
Ref Exclusive	Overlap	5.40e-01	6.20e-01	5.40e-01	1.06e-01
Overlap	Exclusives	8.33e-01	4.16e-01	1.68e-60	4.59e-18



Evaluating how well EA genes are linked to Ref genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA Exclusive	Ref	0.70	-0.24	0.49	0.27	7.10
Ref Exclusive	EA	0.55	-2.08	-0.78	-0.69	1.26
EA Exclusive	Ref Exclusive	0.70	-0.18	0.56	0.30	6.78
Ref Exclusive	EA Exclusive	0.54	-1.64	-0.90	-0.63	1.06
EA Exclusive	Overlap	0.76	-0.96	-0.63	-0.27	1.23
Ref Exclusive	Overlap	0.86	-0.50	0.79	0.44	1.66
Overlap	Exclusives	0.68	0.01	0.52	0.53	9.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA Exclusive	Ref	0.01	-0.97	-0.15	-0.39	5.48
Ref Exclusive	EA	0.00	-1.21	-0.50	-0.35	0.89
EA Exclusive	Ref Exclusive	0.01	-1.00	-0.12	-0.34	4.00
Ref Exclusive	EA Exclusive	0.00	-0.81	-0.66	-0.39	0.45
EA Exclusive	Overlap	0.00	-1.04	-1.24	-0.69	0.05
Ref Exclusive	Overlap	0.00	-0.51	0.59	-0.09	1.68
Overlap	Exclusives	0.02	0.04	0.02	-0.05	6.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA Exclusive	77	76	LOC554223
Ref Exclusive	109	106	SHANK3;MIR137;PRODH
Overlap	2	2