Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA Exclusive	Ref	9.90e-04	6.47e-03	1.37e-01	1.66e-07
Ref Exclusive	EA	3.63e-03	1.23e-01	5.45e-02	5.26e-01
EA Exclusive	Ref Exclusive	8.17e-04	1.48e-02	1.16e-01	4.62e-07
Ref Exclusive	EA Exclusive	3.28e-03	1.50e-01	5.68e-02	3.33e-01
EA Exclusive	Overlap	6.06e-01	6.33e-01	7.27e-01	4.89e-01
Ref Exclusive	Overlap	7.27e-01	8.39e-01	6.80e-02	1.10e-01
Overlap	Exclusives	8.76e-03	7.27e-01	3.53e-11	9.79e-07



Evaluating how well EA genes are linked to Ref genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA Exclusive	Ref	0.65	-1.59	-3.42	-0.93	5.55
Ref Exclusive	EA	0.50	-2.48	-1.27	-1.07	0.03
EA Exclusive	Ref Exclusive	0.65	-1.46	-3.54	-0.91	5.60
Ref Exclusive	EA Exclusive	0.49	-2.31	-1.23	-0.94	-0.30
EA Exclusive	Overlap	0.67	-0.93	-1.43	-0.60	0.86
Ref Exclusive	Overlap	0.80	0.60	0.65	0.62	1.45
Overlap	Exclusives	0.60	-1.26	-0.60	-0.57	5.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA Exclusive	Ref	0.01	-1.53	-2.71	-1.22	1.80
Ref Exclusive	EA	0.00	-2.48	-1.47	-0.91	-0.62
EA Exclusive	Ref Exclusive	0.01	-1.50	-3.00	-1.12	1.73
Ref Exclusive	EA Exclusive	0.00	-2.00	-0.62	-1.15	-0.79
EA Exclusive	Overlap	0.00	-0.68	-1.32	-0.53	-0.18
Ref Exclusive	Overlap	0.00	0.18	-0.11	-0.18	0.42
Overlap	Exclusives	0.01	-0.89	-0.34	-0.70	2.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA Exclusive	100	99	LOC554223
Ref Exclusive	109	106	PRODH;MIR137;SHANK3
Overlap	2	2