Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA Exclusive	Ref	4.42e-01	2.33e-01	1.23e-02	1.04e-12
Ref Exclusive	EA	1.69e-03	7.02e-01	1.87e-03	8.73e-02
EA Exclusive	Ref Exclusive	5.18e-01	1.70e-01	6.25e-03	1.77e-12
Ref Exclusive	EA Exclusive	1.34e-03	7.52e-01	2.44e-03	1.13e-01
EA Exclusive	Overlap	5.53e-01	5.40e-01	6.47e-01	6.06e-01
Ref Exclusive	Overlap	5.40e-01	6.87e-01	5.40e-01	1.10e-01
Overlap	Exclusives	6.93e-01	7.65e-01	6.78e-67	1.08e-13



Evaluating how well EA genes are linked to Ref genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA Exclusive	Ref	0.73	0.00	0.65	0.54	7.76
Ref Exclusive	EA	0.54	-1.59	-0.35	-0.01	1.62
EA Exclusive	Ref Exclusive	0.73	0.06	0.83	0.63	8.08
Ref Exclusive	EA Exclusive	0.54	-1.58	-0.39	-0.19	1.36
EA Exclusive	Overlap	0.71	-2.48	-1.82	-1.67	0.95
Ref Exclusive	Overlap	0.86	-0.44	0.64	0.35	1.91
Overlap	Exclusives	0.64	0.00	-0.34	0.19	7.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA Exclusive	Ref	0.01	-1.20	0.01	-0.45	2.77
Ref Exclusive	EA	0.01	-1.04	-0.15	-0.02	1.53
EA Exclusive	Ref Exclusive	0.01	-1.22	0.17	-0.32	4.59
Ref Exclusive	EA Exclusive	0.01	-0.95	-0.30	-0.18	0.71
EA Exclusive	Overlap	0.00	-0.45	-0.99	-0.77	0.09
Ref Exclusive	Overlap	0.00	-0.55	0.29	-0.16	0.40
Overlap	Exclusives	0.02	0.09	-0.35	-0.32	5.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA Exclusive	132	131	LOC554223
Ref Exclusive	109	106	MIR137;PRODH;SHANK3
Overlap	2	2