Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Overlap btw Combined and Male	GS	2.90e-02	1.62e-02	2.04e-01	7.33e-04
GS	Overlap btw Combined and Male	4.26e-01	4.16e-01	2.29e-03	5.52e-03



Evaluating how well Overlap btw Combined and Male genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Overlap btw Combined and Male	GS	0.79	1.65	3.17	1.65	3.90
GS	Overlap btw Combined and Male	0.41	0.43	-0.67	-0.81	-1.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Overlap btw Combined and Male	GS	0.00	1.03	3.72	0.04	1.97
GS	Overlap btw Combined and Male	0.00	2.00	1.34	0.44	0.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Overlap btw Combined and Male	35	35	
GS	14	14