Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Overlap btw Combined and Male	GWAS	5.26e-01	3.94e-01	1.08e-01	9.06e-02
GWAS	Overlap btw Combined and Male	8.13e-02	2.98e-01	1.07e-01	1.73e-02



Evaluating how well Overlap btw Combined and Male genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Overlap btw Combined and Male	GWAS	0.61	0.01	0.40	-0.17	1.77
GWAS	Overlap btw Combined and Male	0.44	0.23	-0.25	-0.26	-1.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Overlap btw Combined and Male	GWAS	0.00	0.05	1.33	-0.03	0.27
GWAS	Overlap btw Combined and Male	0.00	0.27	-0.17	-0.08	-0.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Overlap btw Combined and Male	35	35	
GWAS	25	24	HLA -DRB1