Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Overlap btw Combined and Female	GS	3.83e-01	8.09e-01	5.77e-01	5.47e-02
GS	Overlap btw Combined and Female	4.43e-01	1.49e-01	7.64e-02	7.26e-02



Evaluating how well Overlap btw Combined and Female genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Overlap btw Combined and Female	GS	0.66	-0.30	-0.21	-0.58	2.05
GS	Overlap btw Combined and Female	0.62	1.76	0.58	0.92	1.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Overlap btw Combined and Female	GS	0.00	-0.37	-0.29	-0.37	0.67
GS	Overlap btw Combined and Female	0.00	0.23	-0.11	-0.08	-0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Overlap btw Combined and Female	10	10	
GS	14	14