Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Overlap btw Combined and Female	GWAS	7.49e-01	9.19e-01	6.26e-01	4.32e-03
GWAS	Overlap btw Combined and Female	4.83e-01	8.50e-01	6.89e-01	8.40e-01



Evaluating how well Overlap btw Combined and Female genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Overlap btw Combined and Female	GWAS	0.66	0.60	0.60	0.03	2.78
GWAS	Overlap btw Combined and Female	0.54	-0.07	0.00	0.08	0.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Overlap btw Combined and Female	GWAS	0.00	0.25	-0.04	-0.29	1.20
GWAS	Overlap btw Combined and Female	0.00	-0.16	-0.21	-0.15	-0.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Overlap btw Combined and Female	10	10	
GWAS	25	24	HLA -DRB1