Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Downsamping_top_25	GS	1.53e-04	2.13e-05	1.42e-04	6.31e-07
GS	Downsamping_top_25	2.09e-01	2.87e-01	4.97e-02	3.33e-01



Evaluating how well Downsamping_top_25 genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Downsamping_top_25	GS	0.89	2.53	5.50	2.65	5.04
GS	Downsamping_top_25	0.53	3.48	1.28	1.54	0.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Downsamping_top_25	GS	0.00	3.37	13.92	2.79	7.15
GS	Downsamping_top_25	0.00	3.40	2.75	3.22	4.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Downsamping_top_25	25	25	
GS	14	14