Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Downsamping_top_25 Exclusive	GWAS	4.45e-01	8.69e-02	9.70e-01	3.94e-04
GWAS Exclusive	Downsamping_top_25	8.56e-01	8.90e-01	7.78e-01	4.79e-01
Downsamping_top_25 Exclusive	GWAS Exclusive	5.35e-01	9.97e-02	8.98e-01	1.47e-03
GWAS Exclusive	Downsamping_top_25 Exclusive	8.75e-01	8.91e-01	7.65e-01	2.33e-01
Downsamping_top_25 Exclusive	Overlap	6.73e-01	9.92e-02	7.93e-01	1.85e-01
GWAS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	9.95e-03	7.29e-05	9.30e-15	6.12e-05



Evaluating how well Downsamping_top_25 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Downsamping_top_25 Exclusive	GWAS	0.69	0.93	1.96	0.95	3.08
GWAS Exclusive	Downsamping_top_25	0.48	0.61	-0.16	0.12	-0.35
Downsamping_top_25 Exclusive	GWAS Exclusive	0.68	0.75	2.30	1.06	2.53
GWAS Exclusive	Downsamping_top_25 Exclusive	0.45	0.35	-0.25	-0.01	-1.01
Downsamping_top_25 Exclusive	Overlap	0.83	0.29	-inf	0.24	1.36
GWAS Exclusive	Overlap	1.00	1.25	111424462830387.00	1.53	1.84
Overlap	Exclusives	0.68	inf	4.40	2.14	4.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Downsamping_top_25 Exclusive	GWAS	0.00	0.01	0.44	0.13	1.08
GWAS Exclusive	Downsamping_top_25	0.00	1.51	1.74	2.52	1.22
Downsamping_top_25 Exclusive	GWAS Exclusive	0.00	-0.13	0.91	-0.02	0.33
GWAS Exclusive	Downsamping_top_25 Exclusive	0.00	-0.27	-0.21	-0.23	-0.30
Downsamping_top_25 Exclusive	Overlap	0.00	-0.22	-1116742592905910.75	-0.33	0.02
GWAS Exclusive	Overlap	0.02	30.73	32920936630948200.00	45.04	25.90
Overlap	Exclusives	0.01	6185665917154869.00	16.98	9.27	5.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Downsamping_top_25 Exclusive	24	24	
GWAS Exclusive	24	23	HLA -DRB1
Overlap	1	1