Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Downsamping_top_10	GS	5.41e-05	5.68e-09	1.02e-06	9.21e-09
GS	Downsamping_top_10	1.71e-01	3.39e-01	7.02e-02	1.54e-01



Evaluating how well Downsamping_top_10 genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Downsamping_top_10	GS	0.88	2.41	5.06	2.28	5.33
GS	Downsamping_top_10	0.63	3.11	1.38	1.49	1.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Downsamping_top_10	GS	0.00	1.75	10.74	0.86	0.93
GS	Downsamping_top_10	0.00	6.90	2.06	3.08	1.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Downsamping_top_10	10	10	
GS	14	14