Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Downsamping_top_10 Exclusive	GWAS	1.73e-02	7.04e-03	2.69e-02	1.35e-05
GWAS Exclusive	Downsamping_top_10	5.14e-01	6.78e-01	2.52e-01	3.14e-01
Downsamping_top_10 Exclusive	GWAS Exclusive	4.05e-03	8.77e-03	1.33e-02	2.03e-05
GWAS Exclusive	Downsamping_top_10 Exclusive	6.56e-01	4.89e-01	3.59e-01	4.63e-01
Downsamping_top_10 Exclusive	Overlap	1.95e-01	9.92e-02	3.51e-01	2.17e-01
GWAS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	3.01e-03	2.24e-06	2.44e-17	2.87e-08



Evaluating how well Downsamping_top_10 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Downsamping_top_10 Exclusive	GWAS	0.75	1.23	2.98	1.55	4.31
GWAS Exclusive	Downsamping_top_10	0.64	1.27	1.00	1.49	1.34
Downsamping_top_10 Exclusive	GWAS Exclusive	0.75	1.56	3.26	1.89	3.94
GWAS Exclusive	Downsamping_top_10 Exclusive	0.60	1.52	1.38	1.15	1.19
Downsamping_top_10 Exclusive	Overlap	0.81	-0.86	-inf	-0.25	1.11
GWAS Exclusive	Overlap	1.00	1.30	111424462830387.00	1.63	1.62
Overlap	Exclusives	0.82	307483219859329.00	6.02	2.41	5.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Downsamping_top_10 Exclusive	GWAS	0.00	0.47	1.84	0.66	2.08
GWAS Exclusive	Downsamping_top_10	0.00	3.54	2.79	4.59	3.61
Downsamping_top_10 Exclusive	GWAS Exclusive	0.00	0.98	2.04	1.98	1.83
GWAS Exclusive	Downsamping_top_10 Exclusive	0.00	-0.09	0.49	-0.06	-0.00
Downsamping_top_10 Exclusive	Overlap	0.00	-0.41	-4117651886993841.00	-0.41	-0.02
GWAS Exclusive	Overlap	0.02	23.59	32920936630948200.00	69.36	77.18
Overlap	Exclusives	0.02	7567856683417180.00	21.10	12.45	33.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Downsamping_top_10 Exclusive	9	9	
GWAS Exclusive	24	23	HLA -DRB1
Overlap	1	1