Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	EPI-AF1	1.81e-04	5.10e-01	9.62e-01	1.09e-01
EPI-AF1	Casanova	4.99e-02	3.42e-01	8.23e-01	3.22e-03



Evaluating how well Casanova genes are linked to EPI-AF1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EPI-AF1	0.45	-0.15	-0.72	-0.26	-1.65
EPI-AF1	Casanova	0.74	1.42	1.46	0.46	2.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EPI-AF1	0.00	-0.08	0.24	-0.06	-0.51
EPI-AF1	Casanova	0.00	0.77	0.76	-0.20	0.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
EPI-AF1	77	77