Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI Exclusive	GS	8.78e-01	9.22e-01	8.71e-01	3.06e-01
GS Exclusive	EPI	8.34e-04	3.74e-01	7.17e-03	2.87e-02
EPI Exclusive	GS Exclusive	8.89e-01	8.05e-01	6.17e-01	2.79e-01
GS Exclusive	EPI Exclusive	1.53e-03	3.66e-01	1.38e-02	2.25e-02
EPI Exclusive	Overlap	5.30e-01	9.92e-02	8.29e-01	1.41e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	2.41e-03	3.91e-01	4.06e-37	1.46e-01



Evaluating how well EPI genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	GS	0.62	-0.64	-0.48	-0.37	1.33
GS Exclusive	EPI	0.46	-2.01	-1.41	-1.22	-2.17
EPI Exclusive	GS Exclusive	0.60	-0.56	-0.89	-0.43	1.20
GS Exclusive	EPI Exclusive	0.45	-1.45	-1.43	-1.30	-2.08
EPI Exclusive	Overlap	0.90	0.56	inf	0.43	1.45
GS Exclusive	Overlap	1.00	1.70	1796314181429203.00	2.31	1.60
Overlap	Exclusives	0.50	227737726007504.00	1.01	0.36	-0.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	GS	0.00	-0.49	-0.82	-0.38	0.63
GS Exclusive	EPI	0.01	-1.09	-0.43	-0.48	-1.08
EPI Exclusive	GS Exclusive	0.00	-0.33	-0.86	-0.39	0.50
GS Exclusive	EPI Exclusive	0.01	-1.07	-0.59	-0.59	-1.29
EPI Exclusive	Overlap	0.00	-0.08	1113326774627581.38	-0.24	1.13
GS Exclusive	Overlap	0.01	23.65	inf	19.72	26.19
Overlap	Exclusives	0.02	5408201333238251.00	15.59	11.09	10.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI Exclusive	163	160	HLA.DRB5;PKD1L2;HLA.DPB1
GS Exclusive	13	13	
Overlap	1	1