Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI Exclusive	GS_all	9.41e-01	9.19e-01	3.50e-01	9.55e-02
GS_all Exclusive	EPI	1.10e-03	5.84e-01	7.42e-01	1.24e-01
EPI Exclusive	GS_all Exclusive	9.57e-01	8.94e-01	4.65e-01	2.18e-01
GS_all Exclusive	EPI Exclusive	6.57e-04	5.40e-01	9.32e-01	7.60e-02
EPI Exclusive	Overlap	8.51e-01	5.40e-01	5.66e-01	4.83e-02
GS_all Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.28e-02
Overlap	Exclusives	1.02e-03	9.13e-04	3.47e-50	7.57e-04



Evaluating how well EPI genes are linked to GS_all genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	GS_all	0.60	-0.02	-0.22	-0.58	2.23
GS_all Exclusive	EPI	0.47	-0.66	-0.77	-0.58	-1.42
EPI Exclusive	GS_all Exclusive	0.59	-0.12	-0.07	-0.32	1.65
GS_all Exclusive	EPI Exclusive	0.47	-0.80	-0.78	-0.81	-1.56
EPI Exclusive	Overlap	0.90	0.35	-88038881314912.00	0.13	1.94
GS_all Exclusive	Overlap	1.00	2.06	inf	2.20	2.47
Overlap	Exclusives	0.55	inf	3.51	1.93	2.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	GS_all	0.00	-0.29	-0.90	-0.34	0.06
GS_all Exclusive	EPI	0.01	1.09	-0.07	0.33	-0.17
EPI Exclusive	GS_all Exclusive	0.00	-0.21	-0.88	-0.47	0.70
GS_all Exclusive	EPI Exclusive	0.01	-0.35	-0.41	-0.64	-0.90
EPI Exclusive	Overlap	0.00	-0.42	-inf	-0.45	0.01
GS_all Exclusive	Overlap	0.03	66.90	70882278629639056.00	119.84	2.40
Overlap	Exclusives	0.04	17909628475686470.00	48.52	29.04	38.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI Exclusive	162	159	HLA.DPB1;PKD1L2;HLA.DRB5
GS_all Exclusive	36	35	HLA -DRB1
Overlap	2	2