Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	EPI-AF1	1.19e-04	5.63e-01	9.42e-01	8.14e-02
EPI-AF1	Casanova	3.95e-02	3.30e-01	6.88e-01	4.15e-03



Evaluating how well Casanova genes are linked to EPI-AF1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EPI-AF1	0.45	0.05	-0.80	-0.54	-1.70
EPI-AF1	Casanova	0.74	1.38	1.59	0.50	3.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EPI-AF1	0.00	0.17	0.20	-0.13	-0.54
EPI-AF1	Casanova	0.00	0.60	0.92	-0.25	1.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
EPI-AF1	77	77