Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	EPI-AF01	6.34e-08	9.67e-01	1.66e-01	6.98e-01
EPI-AF01	Casanova	7.86e-01	6.43e-01	9.85e-01	1.28e-01



Evaluating how well Casanova genes are linked to EPI-AF01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EPI-AF01	0.51	1.73	0.38	-0.01	0.42
EPI-AF01	Casanova	0.66	0.16	0.49	-0.11	1.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EPI-AF01	0.01	0.80	0.34	-0.20	0.01
EPI-AF01	Casanova	0.00	-0.04	1.56	-0.17	-0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
EPI-AF01	174	172	C1GALT1C1L;CCDC7