Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	EPI-AF001	2.15e-07	6.13e-01	1.14e-01	1.09e-01
EPI-AF001	Casanova	9.38e-01	9.08e-01	9.41e-01	1.26e-01



Evaluating how well Casanova genes are linked to EPI-AF001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EPI-AF001	0.52	0.24	-0.55	-0.35	0.59
EPI-AF001	Casanova	0.67	0.26	0.46	-0.16	1.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EPI-AF001	0.01	-0.18	-0.71	-0.46	-0.27
EPI-AF001	Casanova	0.00	-0.26	-0.24	-0.48	-0.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
EPI-AF001	136	133	PPIAL4E;LOC101928841;CCDC7