Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	EPI-AF0001	3.47e-09	2.85e-01	2.68e-01	2.74e-02
EPI-AF0001	Casanova	9.23e-05	7.54e-03	9.02e-03	3.53e-01



Evaluating how well Casanova genes are linked to EPI-AF0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EPI-AF0001	0.53	-0.02	-1.69	-0.88	1.16
EPI-AF0001	Casanova	0.43	-2.72	-3.79	-1.77	-0.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EPI-AF0001	0.01	-0.46	-2.07	-0.94	-0.42
EPI-AF0001	Casanova	0.00	-1.00	-2.05	-0.62	-0.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
EPI-AF0001	142	141	JMJD7-PLA2G4B