Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	Wave_AF1	8.60e-08	7.82e-02	3.23e-07	3.96e-28
Wave_AF1	Casanova	1.28e-01	2.42e-03	3.88e-10	1.72e-07



Evaluating how well Casanova genes are linked to Wave_AF1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	Wave_AF1	0.75	2.07	2.65	2.51	11.20
Wave_AF1	Casanova	0.93	1.13	4.38	2.08	4.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	Wave_AF1	0.02	3.62	2.91	6.11	14.27
Wave_AF1	Casanova	0.01	1.06	12.10	6.44	3.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
Wave_AF1	165	165