Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	Wave_AF01	2.72e-07	6.79e-01	8.06e-04	5.01e-23
Wave_AF01	Casanova	7.13e-01	8.67e-03	3.09e-09	1.34e-06



Evaluating how well Casanova genes are linked to Wave_AF01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	Wave_AF01	0.75	1.38	0.72	1.64	9.92
Wave_AF01	Casanova	0.92	0.21	4.17	1.99	5.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	Wave_AF01	0.02	2.35	0.81	4.36	15.25
Wave_AF01	Casanova	0.01	-0.25	9.68	5.07	16.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
Wave_AF01	142	142