Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	Wave_AF001	3.56e-05	1.08e-01	1.06e-05	1.09e-25
Wave_AF001	Casanova	1.45e-04	5.79e-04	3.56e-11	3.96e-08



Evaluating how well Casanova genes are linked to Wave_AF001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	Wave_AF001	0.78	1.85	3.25	3.10	12.29
Wave_AF001	Casanova	0.96	1.77	5.27	2.28	5.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	Wave_AF001	0.02	2.75	4.97	6.95	22.64
Wave_AF001	Casanova	0.01	2.61	13.60	7.01	5.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
Wave_AF001	133	133