Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	Wave_AF0001	4.23e-04	1.08e-04	1.69e-06	5.72e-36
Wave_AF0001	Casanova	1.57e-02	2.19e-04	3.72e-11	2.97e-08



Evaluating how well Casanova genes are linked to Wave_AF0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	Wave_AF0001	0.83	2.91	3.83	3.16	14.22
Wave_AF0001	Casanova	0.94	1.43	5.05	2.19	6.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	Wave_AF0001	0.02	3.06	3.58	6.98	17.99
Wave_AF0001	Casanova	0.01	1.14	13.53	3.16	21.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
Wave_AF0001	123	123