Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	EAML_AF01	9.66e-06	2.83e-01	1.34e-02	4.92e-01
EAML_AF01	Casanova	6.53e-01	4.81e-01	1.17e-01	6.33e-01



Evaluating how well Casanova genes are linked to EAML_AF01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EAML_AF01	0.51	2.43	1.70	1.29	0.68
EAML_AF01	Casanova	0.61	-0.28	-1.10	-1.01	1.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EAML_AF01	0.01	1.95	1.22	0.34	0.17
EAML_AF01	Casanova	0.00	-0.18	-0.23	-0.61	0.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
EAML_AF01	274	270	LOC101928841;C1GALT1C1L;CCDC7;MST1L