Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	EAML_AF001	8.25e-13	8.52e-01	1.20e-01	3.74e-01
EAML_AF001	Casanova	5.68e-02	3.23e-01	1.66e-02	1.09e-01



Evaluating how well Casanova genes are linked to EAML_AF001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EAML_AF001	0.48	0.03	-0.80	-0.78	-1.04
EAML_AF001	Casanova	0.60	-1.02	-1.46	-1.28	1.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EAML_AF001	0.01	-0.35	-1.12	-1.05	-1.41
EAML_AF001	Casanova	0.00	-0.83	-1.36	-0.84	-0.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
EAML_AF001	292	287	PPIAL4E;LOC101928841;CCDC7;HDGFL2;CORO7-PAM16