Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	EAML_AF0001	8.31e-12	8.85e-01	1.11e-01	8.26e-02
EAML_AF0001	Casanova	2.44e-02	3.23e-02	6.86e-02	1.75e-01



Evaluating how well Casanova genes are linked to EAML_AF0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EAML_AF0001	0.53	0.23	0.05	0.17	1.63
EAML_AF0001	Casanova	0.59	-1.20	-2.56	-1.12	1.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	EAML_AF0001	0.02	-0.21	-0.71	-0.32	0.39
EAML_AF0001	Casanova	0.00	-0.86	-2.06	-0.91	-0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
EAML_AF0001	283	283