Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	React_AC5	3.30e-06	2.95e-01	1.11e-01	4.30e-01
React_AC5	Casanova	2.41e-01	2.07e-01	2.23e-01	3.40e-02



Evaluating how well Casanova genes are linked to React_AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	React_AC5	0.50	-1.07	-1.60	-0.98	0.01
React_AC5	Casanova	0.65	0.30	-0.58	0.05	1.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	React_AC5	0.00	-0.77	-1.14	-0.29	-0.20
React_AC5	Casanova	0.00	-0.20	-0.74	-0.28	0.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
React_AC5	47	47