Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova Exclusive	React_AC4	8.70e-11	1.87e-02	4.73e-03	6.87e-03
React_AC4 Exclusive	Casanova	1.60e-08	2.77e-06	2.86e-09	1.44e-08
Casanova Exclusive	React_AC4 Exclusive	1.43e-10	5.80e-02	2.07e-02	9.90e-03
React_AC4 Exclusive	Casanova Exclusive	3.74e-07	3.94e-05	1.13e-07	5.79e-07
Casanova Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
React_AC4 Exclusive	Overlap	1.15e-02	1.82e-02	1.22e-02	1.28e-02
Overlap	Exclusives	1.63e-04	2.87e-04	4.65e-06	9.55e-05



Evaluating how well Casanova genes are linked to React_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	React_AC4	0.60	-1.22	-0.30	-0.47	3.30
React_AC4 Exclusive	Casanova	0.96	2.74	4.97	2.34	5.76
Casanova Exclusive	React_AC4 Exclusive	0.59	-1.48	-0.66	-0.52	3.09
React_AC4 Exclusive	Casanova Exclusive	0.95	3.41	4.27	2.47	4.70
Casanova Exclusive	Overlap	1.00	2.56	3.49	1.89	2.50
React_AC4 Exclusive	Overlap	0.98	1.54	1.62	1.61	2.59
Overlap	Exclusives	0.64	0.39	1.27	0.69	4.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	React_AC4	0.01	2.48	13.47	4.72	11.77
React_AC4 Exclusive	Casanova	0.01	4.91	10.04	6.37	8.18
Casanova Exclusive	React_AC4 Exclusive	0.01	0.78	6.49	2.04	8.23
React_AC4 Exclusive	Casanova Exclusive	0.01	7.75	8.16	8.63	4.33
Casanova Exclusive	Overlap	0.03	112.25	201.93	96.29	51.35
React_AC4 Exclusive	Overlap	0.00	2.42	8.31	3.67	2.73
Overlap	Exclusives	0.03	22.51	42.75	12.26	15.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova Exclusive	11	10	UNC93B
React_AC4 Exclusive	71	71	
Overlap	2	2