Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	React_AC1	6.61e-02	8.86e-01	4.68e-01	5.22e-01
React_AC1	Casanova	5.24e-02	2.26e-01	7.19e-02	2.71e-02



Evaluating how well Casanova genes are linked to React_AC1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	React_AC1	0.55	-0.45	-0.59	-0.75	0.58
React_AC1	Casanova	0.62	-0.43	-0.87	-0.59	1.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	React_AC1	0.00	-0.24	-0.57	-0.48	-0.25
React_AC1	Casanova	0.00	-0.36	-0.66	-0.25	-0.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
React_AC1	9	9