Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	STRING_AC5	1.85e-13	5.78e-02	3.27e-01	3.22e-01
STRING_AC5	Casanova	1.32e-03	7.10e-03	2.70e-03	5.93e-04



Evaluating how well Casanova genes are linked to STRING_AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	STRING_AC5	0.50	-0.64	-1.10	-0.55	-0.06
STRING_AC5	Casanova	0.79	1.45	1.88	1.09	3.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	STRING_AC5	0.01	0.55	0.83	0.36	0.85
STRING_AC5	Casanova	0.00	3.42	4.66	2.02	5.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
STRING_AC5	143	142	ZNF763