Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	STRING_AC4	4.44e-06	5.53e-01	8.97e-01	4.35e-01
STRING_AC4	Casanova	1.76e-02	3.06e-02	9.95e-03	8.31e-01



Evaluating how well Casanova genes are linked to STRING_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	STRING_AC4	0.53	-0.66	-0.29	-0.37	0.77
STRING_AC4	Casanova	0.49	-0.85	-3.09	-1.18	-0.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	STRING_AC4	0.00	-0.59	-0.47	-0.61	-0.19
STRING_AC4	Casanova	0.00	-0.47	-1.48	-0.59	-0.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
STRING_AC4	55	54	ZNF763