Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	STRING_AC2	8.54e-06	6.76e-03	4.19e-03	2.92e-02
STRING_AC2	Casanova	1.20e-04	5.79e-03	1.20e-04	3.30e-01



Evaluating how well Casanova genes are linked to STRING_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	STRING_AC2	0.39	-1.24	-3.48	-1.62	-1.72
STRING_AC2	Casanova	0.45	-1.63	-4.11	-1.77	-0.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	STRING_AC2	0.00	-0.97	-0.88	-0.50	-0.24
STRING_AC2	Casanova	0.00	-0.50	-2.09	-0.74	-0.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
STRING_AC2	21	21